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- Title
Bone marrow WT1 levels at diagnosis, post-induction and post-intensification in adult de novo AML.
- Authors
Nomdedéu, J F; Hoyos, M; Carricondo, M; Bussaglia, E; Estivill, C; Esteve, J; Tormo, M; Duarte, R; Salamero, O; de Llano, M P Q; García, A; Bargay, J; Heras, I; Martí-Tutusaus, J M; Llorente, A; Ribera, J M; Gallardo, D; Aventin, A; Brunet, S; Sierra, J
- Abstract
We retrospectively assessed whether normalized bone marrow WT1 levels could be used for risk stratification in a consecutive series of 584 acute myeloid leukemia (AML) patients. A cutoff value of 5065 copies at diagnosis identified two prognostic groups (overall survival (OS): 44±3 vs 36±3%, P=0.023; leukemia-free survival (LFS): 47±3 vs 36±4%, P=0.038; and cumulative incidence of relapse (CIR): 37±3 vs 47±4%, P=:0.043). Three groups were identified on the basis of WT1 levels post-induction: Group 0 (WT1 between 0 and 17.5 copies, 134 patients, OS: 59±4%, LFS:59±4% and CIR: 26±4%); Group 1 (WT1 between 17.6 and 170.5 copies, 160 patients, OS: 48±5%, LFS:41±4% and CIR: 45±4%); and Group 2 (WT1 >170.5 copies, 71 patients, OS: 23±6%, LFS: 19±7% and CIR: 68±8%) (P<0.001). Post-intensification samples distinguished three groups: patients with WT1 >100 copies (47 patients, 16%); an intermediate group of patients with WT1 between 10 and 100 copies (148 patients, 52%); and a third group with WT1 <10 copies (92 patients, 32%). Outcomes differed significantly in terms of OS (30±7%, 59±4%, 72±5%), LFS (24±7%, 46±4%, 65±5%) and relapse probability (CIR 72±7%, 45±4%, 25±5%), all P<0.001. WT1 levels in bone marrow assayed using the standardized ELN method provide relevant prognostic information in de novo AML.
- Subjects
BONE marrow diseases; ACUTE myeloid leukemia; DISEASE risk factors; IMMUNE system; LEUKEMIA treatment; PATIENTS; DIAGNOSIS
- Publication
Leukemia (08876924), 2013, Vol 27, Issue 11, p2157
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2013.111