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- Title
Clonal evolution in cutaneous malignant histiocytosis.
- Authors
Wantzin, Gunhild Lange; Ralfkiaer, Elisabeth; Larsen, Jørgen K.; Thomsen, Kristian
- Abstract
A 56-year-old woman is reported with malignant histiocytosis which for 17 months was confined to the skin but eventually involed lympth modes, blood and bone marrow. Using DNA measurements by flow cytometry a clonal evolution from an abnormal hyperdiploid to a hypotetraploid cell clone took place when the patient went from the cutaneous to the disseminated phase of the disease. Thus DNA measurements upon tumours may predict the transition from the cutaneous to the disseminated stage.
- Subjects
HISTIOCYTOSIS; LYMPH nodes; DNA; BONE marrow; LYMPHATIC diseases
- Publication
Clinical & Experimental Dermatology, 1985, Vol 10, Issue 2, p121
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.1985.tb00539.x