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- Title
Instrument comparison between 2014 and 2018 models of the HemoCue® 501 HbA1c point-of-care analyser.
- Authors
Mao, Constantine; Hughes, Heather
- Abstract
Objectives: Certain haemoglobin variants interfere with HbA1c results obtained from ion-exchange high performance chromatography. An alternative assay method was required to measure the HbA1c levels in these cases. At Canterbury SCL, a HemoCue 501 HbA1c point-of-care analyser was used as the alternate test method. However, the 2014 HemoCue model used at Canterbury SCL required patient samples to be run in duplicate due to its poor precision. HemoCue released a newer 2018 model that claimed to have better precision than previous models. The aim of this study was to compare the precision between the 2014 and the 2018 HemoCue 501 analyser models. Methods: Twenty K2EDTA whole blood patient samples were collected and tested over a period of three weeks. Each sample was tested three times in total, once on the 2014 model and twice on the 2018 model. The coefficient of variation (CV) was calculated for the 2018 model using the twenty patient duplicate results and six QC duplicate results. The CV for the 2014 model was calculated using 227 duplicate results from previous patients' records. Results: The mean CV of the 2018 model was 2.7% (n=27). The mean CV of the 2014 model was 9.1% (n=227). The mean difference between the 2018 and 2014 results was 2.45. Conclusion: The newer 2018 HemoCue had better precision with a CV of 2.7% compared to the 9.1% CV of the older 2014 model. However, the new model had results on average 2.5 mmol/mol higher than the older model. Further testing is recommended to investigate the higher results.
- Subjects
HEMOGLOBINS; HEMOGLOBINOMETRY; POINT-of-care testing; AUTOANALYZERS
- Publication
New Zealand Journal of Medical Laboratory Science, 2020, Vol 74, Issue 2, p150
- ISSN
1171-0195
- Publication type
Article