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- Title
Effect of Vitamin E on Arsenic Induced Hepatotoxicity in Rats.
- Authors
Rezaie, Annahita; Heidari, Marzieh; Jalali, Mohammad Razi; Mahdi Broojeni, Mahdi Pour; Zadeh, Hossein Najaf; Mohammadian, Babak; Rocky, Ali Reza
- Abstract
Background and Objectives: Arsenic is one of the most hazardous metals. The objective of this study was to evaluate the preventive effects of vitamin E on a Rat model of arsenic induced hepatotoxicity. Materials and Methods: In this study 30 Wistar rats (immature and mature) were used and each was randomly divided to 3 subgroups. Subgroup received normal saline and subgroup 2 and 3 both received Arsenic, 3mg/kg, subcutaneously, but subgroup 3 also received vitamin E, 400mg/kg, intraperitoneally for 10 days. Results: Histopathologic examination revealed cell swelling, fatty changes and necrosis in hepatocytes of Arsenic group. In subgroup 3 the severities of lesions were less than group 2. Leukocytosis in both arsenic and arsenic-vitamin E groups was observed, but there was no significant difference between them. Activity of glutathione peroxidase in arsenic group was significantly decreased in compared with control group. However in group 3, the activity of glutathione peroxidase was increased but it was not significant. Conclusion: Vitamin E supplement decreases the hepatotoxic effects of Arsenic.
- Subjects
PHYSIOLOGICAL effects of vitamin E; HEPATOTOXICOLOGY; GLUTATHIONE peroxidase; ARSENIC in the body; LEUCOCYTOSIS; LABORATORY rats; PREVENTION
- Publication
Medical Journal of Tabriz University of Medical Sciences & Health Services, 2012, Vol 34, Issue 4, p17
- ISSN
1608-5671
- Publication type
Article