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- Title
Effect of dietary alpha-linolenic acid on blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials.
- Authors
Su, Hang; Liu, Ruijie; Chang, Ming; Huang, Jianhua; Jin, Qingzhe; Wang, Xingguo
- Abstract
Purpose: The aim of the current meta-analysis was to investigate the effect of increasing dietary ALA intake on the blood concentration of inflammatory markers including tumor necrosis factor (TNF), interleukin 6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) in adults.Methods: After a systemic search on PubMed, Embase, and Cochrane library and bibliographies of relevant articles, 25 randomized controlled trials that met the inclusion criteria were identified.Results: No significant effect of dietary ALA supplementation was observed on TNF (SMD: −0.03, 95% CI −0.36 to 0.29), IL-6 (SMD: −0.17, 95% CI −0.46 to 0.12), CRP (SMD: −0.06, 95% CI −0.24 to 0.12), sICAM-1 (SMD: −0.06, 95% CI −0.26 to 0.13), and sVCAM-1 (SMD: −0.24, 95% CI −0.56 to 0.09). Subgroup analysis revealed that increasing dietary ALA tends to elevate CRP concentration in healthy subjects. However, the null effect of ALA supplementation on other inflammatory markers was not changed in various subgroups, indicating that the results are stable. Meta-regression results revealed a negative relationship between the effect size on CRP and its baseline concentration. No significant publication bias was observed for all inflammatory markers as suggested by funnel plot and Begg’s test.Conclusion: Our meta-analysis did not find any beneficial effect of ALA supplementation on reducing inflammatory markers including TNF, IL-6, CRP, sICAM-1, and sVCAM-1. However, in healthy subjects, ALA supplementation might increase CRP concentration.
- Subjects
BIOMARKERS; C-reactive protein; CONFIDENCE intervals; FAT content of food; INFLAMMATION; MEDICAL databases; INFORMATION storage &; retrieval systems; MEDICAL information storage &; retrieval systems; MEDLINE; META-analysis; ONLINE information services; REGRESSION analysis; SYSTEMATIC reviews; EVIDENCE-based medicine; PROFESSIONAL practice; RANDOMIZED controlled trials; PUBLICATION bias; ALPHA-linolenic acid; EVALUATION
- Publication
European Journal of Nutrition, 2018, Vol 57, Issue 3, p877
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-017-1386-2