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- Title
Risks of Opioids in ST-Elevation Myocardial Infarction: A Review.
- Authors
Tavenier, Anne Henrieke; Hermanides, Renicus Suffridus; Ottervanger, Jan Paul; Ter Horst, Peter Gerrit Johannes; Kedhi, Elvin; van ‘t Hof, Adriaan W. J.; van 't Hof, Adriaan W J
- Abstract
Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.
- Subjects
MYOCARDIAL infarction; DRUG side effects; MEDICATION safety; OPIOID receptors; ORAL drug administration
- Publication
Drug Safety, 2018, Vol 41, Issue 12, p1303
- ISSN
0114-5916
- Publication type
journal article
- DOI
10.1007/s40264-018-0710-y