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- Title
Testing for Spatially Divergent Selection: Comparing Q<sub>sT</sub> to F<sub>ST</sub>.
- Authors
Whitlock, Michael C.; Guillaume, Frederic
- Abstract
QST is a standardized measure of the genetic differentiation of a quantitative trait among populations. The distribution of QST'S for neutral traits can be predicted from the FST for neutral marker loci. To test for the neutral differentiation of a quantitative trait among populations, it is necessary to ask whether the QST of that trait is in the tail of the probability distribution of neutral traits. This neutral distribution can be estimated using the Lewontin-Krakauer distribution and the FST from a relatively small number of marker loci. We develop a simulation method to test whether the QST of a given trait is consistent with the null hypothesis of selective neutrality over space. The method is most powerful with small mean FST, strong selection, and a large number (>10) of measured populations. The power and type I error rate of the new method are far superior to the traditional method of comparing QST and FST.
- Subjects
BIOLOGICAL divergence; GENETICS; GENES; GENETIC regulation; NATURAL selection; DISTRIBUTION (Probability theory)
- Publication
Genetics, 2009, Vol 183, Issue 3, p1055
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.108.099812