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- Title
Prognostic Significance of Intratumour Microvessel Density and Haemoglobin Level in Carcinoma of the Uterine Cervix.
- Authors
Gasinska, Anna; Urbanski, Krzysztof; Adamczyk, Agnieszka; Pudelek, Jacek; Lind, Bengt K.; Brahme, Anders
- Abstract
The prognostic significance of intratumour microvessel density (IMD) and haemoglobin (Hb) level was studied in 152 (FIGO stage IB -IIIB) cervical cancer patients before radiotherapy. Patients' age and tumour stage, grade and degree of keratinization were also studied. IMD measurement expressed as the mean vessel count per 1 mm[sup 2] was performed on formalin-fixed, paraffin-embedded tumour biopsies stained with anti-factor VIII antibody (DAKO Ltd.) using immunohistochemistry and the vascular hot-spot technique. The median age of patients was 55 years (29-80). Median values for IMD and Hb level were: 142.5 (range 56.3-476.6) vessels/mm[sup 2] and 129 (range 81-160) g/l, respectively. The median time of follow-up was 26 months, with a range of 2-145 months. Tumour stage (p=0.7009), grade (p=0.6660) and degree of keratinization (0.2669) were not significant in the Kaplan-Meier univariate analysis. However, patients' age >50 years (p=0.0079), high vascularity (IMD >190.0 vessels/mm[sup 2], minimal cut-off point, p=0.0503) and Hb concentration >116 g/l (p=0.0213) were favourable prognostic factors for cervical cancer treated with radiotherapy. In the Cox multivariate analysis only higher vascularity (IMD>190/mm[sup 2] and Hb concentration >116 g/l were favourable prognostic factors in terms of patients' survival. However, when a Cox analysis was done separately for keratinizing and non-keratinizing tumours, it was found that higher vascularity was significant only for keratinizing, and higher Hb level only for non-keratinizing cancers.
- Subjects
CERVICAL cancer; HEMOGLOBINS
- Publication
Acta Oncologica, 2002, Vol 41, Issue 5, p437
- ISSN
0284-186X
- Publication type
Article
- DOI
10.1080/028418602320405023