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- Title
Idiopathic retroperitoneal fibrosis: A case report and review of articles.
- Authors
Sadeghi, Sanambar; Ayati, Mohsen; Mohagheghi, Mohamad Ali; Shahriaran, Shahriar; Jahanzad, Isa; Safavi, Somaye
- Abstract
Idiopathic retroperitoneal fibrosis is a rare disorder of an unknown etiology characterized by an inflammatory proliferative fibrosing process that may involve the ureters in 80-100% of cases. The present study was carried on a 38 years old man who was admitted to Imam Khomeini Hospital with severe abdominal pain and renal failure. Abdominal MRI showed encasement of abdominal aorta and bilateral hydrouretero-nephrosis. Tissue biopsy established the diagnosis of retroperitoneal fibrosis and ureteral obstruction was managed by insertion of bilateral ureteral stents. Presupposing the un-resectability, medical therapy was started. However he didn't show objective response to Prednisolone (1mg/kg) and had adverse effects. Subsequently, his disease was controlled by adding mycophenolate mofetil and azathioprine to reduce the steroid dose. After a few months, urinary stents were removed and he had been on complete remission for more than 4 years. Although advanced idiopathic retroperitoneal fibrosis would be effectively treated by a combination of ureteric stents and steroids, in difficult cases, second-line treatment with other immunosuppressive drugs may help to achieve long-term remission of disease.
- Subjects
RETROPERITONEAL fibrosis; ABDOMINAL pain; RETROPERITONEUM diseases; MYCOPHENOLIC acid
- Publication
Basic & Clinical Cancer Research, 2011, Vol 3, Issue 2, p20
- ISSN
2228-6527
- Publication type
Case Study