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- Title
Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis.
- Authors
Annibale, Bruno; Marignani, Massimo; Annibale, B; Marignani, M; Monarca, B; Antonelli, G; Marcheggiano, A; Martino, G; Mandelli, F; Caprilli, R; Delle Fave, G
- Abstract
<bold>Background: </bold>Iron deficiency anemia is the most common form of anemia worldwide. Recent studies have suggested an association between Helicobacter pylori infection and iron deficiency.<bold>Objective: </bold>To investigate the effects of eradicating H. pylori with combination antibiotic therapy on iron deficiency anemia in patients with H. pylori-associated gastritis.<bold>Design: </bold>Case series.<bold>Setting: </bold>University hospital.<bold>Patients: </bold>30 patients with a long history of iron deficiency anemia in whom H. pylori-associated gastritis was the only pathologic gastrointestinal finding detected.<bold>Intervention: </bold>Eradication therapy with two antibiotics and discontinuation of iron replacement therapy.<bold>Measurements: </bold>Complete blood count, ferritin levels, and gastroscopy with biopsy to evaluate H. pylori status.<bold>Results: </bold>At 6 months, 75% of patients had recovered from anemia (P<0.001), ferritin values increased from 5.7+/-0.7 microg/L to 24.5+/-5.2 microg/L (95% CI, 8.85 to 29.97). After 12 months, 91.7% of patients had recovered from anemia.<bold>Conclusions: </bold>Cure of H. pylori infection is associated with reversal of iron dependence and recovery from iron deficiency anemia.
- Subjects
IRON deficiency anemia; HELICOBACTER pylori infections; GASTRITIS
- Publication
Annals of Internal Medicine, 1999, Vol 131, Issue 9, p668
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-131-9-199911020-00006