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- Title
Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea: The Skaraborg Sleep Study.
- Authors
Boström, Kristina Bengtsson; Hedner, Jan; Grote, Ludger; Melander, Olle; vonWowern, Fredrik; Råstam, Lennart; Groop, Leif; Lindblad, Ulf
- Abstract
The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure. This study explored the associations between functional polymorphisms of the α2B-, β1-, and β2-adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects. Only the Arg389Gly polymorphism of the β1-adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7). Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes. When adjusted also for BMI this difference became borderline significant. This difference was not observed in women. The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95% CI 1.4-21.2).
- Subjects
GENETIC polymorphisms; BETA adrenoceptors; ADRENERGIC receptors; OLFACTORY receptor genes; HYPERTENSION genetics; MILD hypertension; SLEEP apnea syndromes; SYMPATHETIC nervous system; REGULATION of blood pressure; AGE factors in disease; GENETICS
- Publication
International Journal of Hypertension, 2010, p1
- ISSN
2090-0384
- Publication type
Article
- DOI
10.4061/2010/458410