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- Title
Phakellistatins: An Underwater Unsolved Puzzle.
- Authors
Meli, Alessandra; Tedesco, Consiglia; Della Sala, Giorgio; Schettini, Rosaria; Albericio, Fernando; De Riccardis, Francesco; Izzo, Irene
- Abstract
A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.
- Subjects
PROLINE; MACROCYCLIC compounds; CYCLIC peptides; MARINE natural products; ORGANIC cyclic compounds
- Publication
Marine Drugs, 2017, Vol 15, Issue 3, p78
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md15030078