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- Title
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels.
- Authors
Fogacci, Federica; Giovannini, Marina; Di Micoli, Antonio; Fiorini, Giulia; Grandi, Elisa; Borghi, Claudio; Cicero, Arrigo F. G.
- Abstract
The aim of this study was to assess whether dietary supplementation with a nutraceutical blend comprising extracts of bergamot and artichoke—both standardized in their characteristic polyphenolic fractions—could positively affect serum lipid concentration and insulin sensitivity, high-sensitivity C-reactive protein (hs-CRP), and indexes of non-alcoholic fatty liver disease (NAFLD) in 90 healthy individuals with suboptimal cholesterol levels. Participants were randomly allocated to treatment with a pill of either active treatment or placebo. After 6 weeks, the active-treated group experienced significant improvements in levels of triglycerides (TG), apolipoprotein B-100 (Apo B-100), and apolipoprotein AI (Apo AI) versus baseline. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (Non-HDL-C), and hs-CRP also significantly decreased in the active-treated group compared to both baseline and placebo. At the 12-week follow-up, individuals allocated to the combined nutraceutical experienced a significant improvement in TC, LDL-C, Non-HDL-C, TG, Apo B-100, Apo AI, glucose, alanine transaminase (ALT), gamma-glutamyl transferase (gGT), hs-CRP, several indexes of NAFLD, and brachial pulse volume (PV) in comparison with baseline. Improvements in TC, LDL-C, Non-HDL-C, TG, fatty liver index (FLI), hs-CRP, and endothelial reactivity were also detected compared to placebo (p < 0.05 for all). Overall, these findings support the use of the tested dietary supplement containing dry extracts of bergamot and artichoke as a safe and effective approach for the prevention and management of a broad spectrum of cardiometabolic disorders.
- Subjects
ANALYSIS of triglycerides; THERAPEUTIC use of artichokes; NON-alcoholic fatty liver disease; HDL cholesterol; INSULIN sensitivity; RESEARCH funding; STATISTICAL sampling; BLIND experiment; FUNCTIONAL foods; TREATMENT effectiveness; RANDOMIZED controlled trials; LDL cholesterol; PLANT extracts; GAMMA-glutamyltransferase; APOLIPOPROTEINS; DIETARY supplements; POLYPHENOLS; C-reactive protein; AMINOTRANSFERASES
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1587
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111587