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- Title
Influence of ketoprofen on the pharmacokinetics of marbofloxacin in buffalo calves (Preliminary study).
- Authors
Baroni, E. E.; Rodríguez, C.; M. D.San Andrés; Moroni, C.; Rubio, S.; de Lucas, J. J.; San Andrés, M. I.
- Abstract
Marbofloxacin (MB) and Ketoprofen (KT) were used frequently in combination for the therapy of microbiological diseases, especially in young animals. Previously, pharmacokinetic interactions of fluoroquinolones and nonsteroidal antiinflammatory (NSAIDs) had been reported in ruminants and other species. For these reasons, pharmacokinetic properties of MB in buffalo calves were determined in serum after intramuscular administration both alone and in combination with KT. The study was carried out in eight (Two group 4 + 4) buffalo calves (7-15 days old). MB and KT were administered at the dose rate of 2 and 3 mg/kg, respectively. Serum samples were assayed for MB by a high performance liquid chromatography method with uv detection. MBF concentration-time data for individual calves were analyzed using PCNONLIN. Serum data were submitted to no compartmental analysis using trapezoidal rule. Normal distribution of samples were evaluated using a Shapiro-Wilk test and, depending on the results, the data were analyzed by parametric or nonparametric tests (SPSS 17.0 program). The MB was p resent in detectable concentrations at all sampling times between 0.08h and 24 h. Concentrations were higher in buffalo calves receiving MB alone (Cmax 1.35 mg/L after MB and 0. 81 mg/L MB+KF). Also, a significant change was found after its co-administration with KT, increasing the mean residence time (MRT). The modification of Cmax, could be therapeutic repercussion, since fluoroquinolones were a concentration-dependent antimicrobial drugs.
- Subjects
PHARMACOKINETICS; FLUOROQUINOLONES; WATER buffalo; NONSTEROIDAL anti-inflammatory agents; SERUM; HIGH performance liquid chromatography; CHROMATOGRAPHIC analysis; INTRAMUSCULAR injections; ANTI-infective agents; PHYSIOLOGY
- Publication
Revista Veterinaria, 2010, Vol 21, Issue 1, p314
- ISSN
1668-4834
- Publication type
Article