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- Title
Exploring multisite heterogeneity of human basal cell carcinoma proteome and transcriptome.
- Authors
Berl, Ariel; Shir-az, Ofir; Genish, Ilai; Biran, Hadas; Mann, Din; Singh, Amrita; Wise, Julia; Kravtsov, Vladimir; Kidron, Debora; Golberg, Alexander; Vitkin, Edward; Yakhini, Zohar; Shalom, Avshalom
- Abstract
Basal cell carcinoma (BCC) is the most common type of skin cancer. Due to multiple, potential underlying molecular tumor aberrations, clinical treatment protocols are not well-defined. This study presents multisite molecular heterogeneity profiles of human BCC based on RNA and proteome profiling. Three areas from lesions excised from 9 patients were analyzed. The focus was gene expression profiles based on proteome and RNA measurements of intra-tumor heterogeneity from the same patient and inter-tumor heterogeneity in nodular, infiltrative, and superficial BCC tumor subtypes from different patients. We observed significant overlap in intra- and inter-tumor variability of proteome and RNA expression profiles, showing significant multisite heterogeneity of protein expression in the BCC tumors. Inter-subtype analysis has also identified unique proteins for each BCC subtype. This profiling leads to a deeper understanding of BCC molecular heterogeneity and potentially contributes to developing new sampling tools for personalized diagnostics therapeutic approaches to BCC.
- Subjects
BASAL cell carcinoma; GENE expression; GENE expression profiling; HETEROGENEITY; TRANSCRIPTOMES; PROTEOMICS
- Publication
PLoS ONE, 2023, Vol 18, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0293744