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- Title
Clustering of uveal melanoma: County wide analysis within Ohio.
- Authors
Clevenger, Leanne M.; Wrenn, Jacquelyn D.; Bena, James; Sodhi, Guneet; Tullio, Katherine; Singh, Arun D.
- Abstract
Purpose: To determine if a greater than expected number of cases (clustering) of uveal melanoma occurred within Ohio for any specific region or time period as compared to others. Design: Analysis of population database. Methods: Ohio Cancer Incidence Surveillance System (OCISS) database (2000–2019) was accessed for the diagnosis of uveal melanoma using the International Classification of Disease for Oncology codes: C69.3 (choroid), C69.4 (ciliary body and iris). Counties within Ohio were grouped by geographic regions (7) and socioeconomic variables. Age- and race-standardized incidence ratios (SIR) were calculated to determine temporal or geographic clustering. Results: Over the twenty-year period, the total number of uveal melanoma cases reported within Ohio were 1,617 with the overall age-adjusted annual incidence of 6.72 cases per million population (95% CI 6.30–7.16). There was an increase in the incidence of uveal melanoma over 20 years (p<0.001) across seven geographic regions, but no significant difference in incidence rates between the regions. There was no difference in incidence based on county classification by age composition (p = 0.14) or education level (p = 0.11). Counties with a low median household income (p<0.001), those classified as urban (p = 0.004), and those with a greater minority population (p = 0.004) had lower incidence. Less populated counties had a higher incidence of uveal melanoma (p<0.001). Conclusions: There is no evidence of geographic or temporal clustering of uveal melanoma within Ohio from 2000 to 2019.
- Subjects
OHIO; UVEA; CILIARY body; MELANOMA; NOSOLOGY; INCOME; IRIS (Eye)
- Publication
PLoS ONE, 2023, Vol 18, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0290284