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- Title
Coagulation Profile Alterations in Dogs Co-Infected with Visceral Leishmaniasis and Monocytic Ehrlichiosis.
- Authors
BALIKÇI, Canberk; GÜLERSOY, Erdem; ŞAHAN, Adem; GÜNAL, İsmail
- Abstract
Canine Visceral Leishmaniasis (CVL) and Canine Monocytic Ehrlichiosis (CME) are zoonotic diseases that cause coagulation disorders, abnormalities in various organs and systems along with vasculitis. Since it was reported that the presence of co-infection may cause more severe abnormalities, this study aimed to investigate the synergistic effects of co-infection on some coagulation analytes (prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-Dimer). Twenty dogs, all were mixed breed, aged 2-4 years, and determined to be co-infected with CVL and CME were used. As a result of the coagulation profile analyte measurements, the values of APTT, PT, and the concentration of FIB were determined to be higher in the Co-infected Group compared to the Control Group (p<0.05). Receiver operating characteristic (ROC) analysis revealed that PT (AUC: 0.980); APTT (AUC: 0.959), FIB (AUC: 1.000), and D-dimer (AUC: 0.929) had outstanding diagnostic discrimination. As a result, it was concluded that the presence of co-infection deteriorates the coagulation profile more severely in co-infection with CVL and CME.
- Subjects
LEISHMANIASIS; EHRLICHIOSIS; VISCERAL leishmaniasis; ZOONOSES; BLOOD coagulation; PARTIAL thromboplastin time; RECEIVER operating characteristic curves
- Publication
Kafkas Universitesi Veteriner Fakultesi Dergisi, 2023, Vol 29, Issue 5, p529
- ISSN
1300-6045
- Publication type
Article
- DOI
10.9775/kvfd.2023.29887