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- Title
EL SISTEMA SEROTONINÉRGICO EN EL PACIENTE DEPRIMIDO. SEGUNDA PARTE.
- Authors
Moreno, Julia; Campos, María G.; Lara, Carmen; Torner, Carlos
- Abstract
Nowadays there are increasing number of studies to support the crucial role of monoamines in depressive disorders. Among them arc studies such as long-term treatment of antidepressants whose mechanism of action regulates monoamine metabolism, monoamine receptor density and post-mortem studies. An acute increase in monoamine concentration at the synaptic cleft might induce desensitization of brain auto- and hetero-receptors which explains the therapeutic antidepressive response. This has been proved by monoamine depletion studies in which an antidepressant effect or a patient relapse has been observed. Likewise, the antidepressive therapeutic response occurs earlier when auto-receptors are pharmacologically blocked at nervous and somatodendriric terminals.
- Subjects
AMINES; MENTAL depression; ANTIDEPRESSANTS; PSYCHIATRIC drugs; PSYCHIATRY
- Publication
Salud Mental, 2006, Vol 29, Issue 1, p44
- ISSN
0185-3325
- Publication type
Article