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- Title
Reshaping pluripotent stem cells.
- Authors
Elefanty, Andrew G.; Stanley, Edouard G.
- Abstract
The article examines a study conducted by researchers from the Whitehead Institute and Sangamo Biosciences which found that strand DNA breaks induced by engineered zinc finger nucleases (ZFN) delivered on plasmids increase the efficiency of gene targeting in human embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). The study results contribute to genome editing in human pluripotent stem cells for various applications. Targeting in human ESC allows the introduction of disease-associated mutations to study pathogenesis.
- Subjects
DNA; ZINC-finger proteins; PLASMIDS; GENE targeting; EMBRYONIC stem cells; GENETIC mutation
- Publication
Nature Biotechnology, 2009, Vol 27, Issue 9, p823
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0909-823