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- Title
Equisetum sylvaticum base reduces atherosclerosis risk factors in rats fed a high-fat diet.
- Authors
Cheng-He Lin; Hua-Li Xu; Wei-Lun Sun; Feng Li; Guang-Zhu Lin
- Abstract
We identify an Equisetum sylvaticum alkaloid (ESA) derived from E. hyemale, which has robust antihyperlipidemic effects in rats fed a high-fat diet. ESA was isolated from E. hyemale and identified by IR, 13C NMR and ¹H NMR. Rats were induced to hyperlipidemia and subjected to ESA treatment. In hyperlipidemic model, fed with a high-fat diet, the blood levels of TC, TG and LDL-C were increased. The administration of ESA (20 or 40 mg/kg) to those rats significantly improved the HDL-C level and reduced the levels of TC, TG, LDL-C. The atherosclerosis index and atherosclerosis risk of these rats were significantly reduced by ESA. In addition, the administration of ESA in rats increased the activity of SOD and decreased the level of MDA. These results reveal the antihyperlipidemic and anti-oxidative effects of ESA in vivo.
- Subjects
ATHEROSCLEROSIS treatment; EQUISETUM; ATHEROSCLEROSIS risk factors; HIGH-fat diet; PHYSIOLOGICAL effects of antioxidants; LABORATORY rats
- Publication
Bangladesh Journal of Pharmacology, 2014, Vol 9, Issue 3, p257
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v9i3.18593