We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease.
- Authors
Wang, Sheng-nan; Li, Qian; Jing, Ming-hua; Alba, Espargaró; Yang, Xiao-hong; Sabaté, Raimon; Han, Yi-fan; Pi, Rong-biao; Lan, Wen-jian; Yang, Xiao-bo; Chen, Jing-kao
- Abstract
Natural xanthones have diversity pharmacological activities. Here, a series of xanthones isolated from the pericarps of Garcinia mangostana Linn, named α-Mangostin, 8-Deoxygartanin, Gartanin, Garciniafuran, Garcinone C, Garcinone D, and γ-Mangostin were investigated. Biological screening performed in vitro and in Escherichia coli cells indicated that most of the xanthones exhibited significant inhibition of self-induced β-amyloid (Aβ) aggregation and also β-site amyloid precursor protein-cleaving enzyme 1, acted as potential antioxidants and biometal chelators. Among these compounds, α-Mangostin, Gartanin, Garcinone C and γ-Mangostin showed better antioxidant properties to scavenge Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) free radical than Trolox, and potent neuroprotective effects against glutamate-induced HT22 cell death partly by up-regulating HO-1 protein level and then scavenging reactive oxygen species. Moreover, Gartanin, Garcinone C and γ-Mangostin could be able to penetrate the blood-brain barrier (BBB) in vitro. These findings suggest that the natural xanthones have multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD.
- Subjects
ALZHEIMER'S disease treatment; XANTHONE; MANGOSTEEN; ANTIOXIDANTS; NEUROPROTECTIVE agents; AMYLOID beta-protein precursor; BLOOD-brain barrier; THERAPEUTICS
- Publication
Neurochemical Research, 2016, Vol 41, Issue 7, p1806
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-016-1896-y