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- Title
The Role of Interleukin-17 in Lung Cancer.
- Authors
Wu, Feng; Xu, Juanjuan; Huang, Qi; Han, Jieli; Duan, Limin; Fan, Jinshuo; Lv, Zhilei; Guo, Mengfei; Hu, Guorong; Chen, Lian; Zhang, Shuai; Tao, Xiaonan; Ma, Wanli; Jin, Yang
- Abstract
Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways. Therefore, IL-17 contributes to the metastasis and progression of lung cancer. Research advances with respect to the role of IL-17 in lung cancer will be presented as a review in this paper.
- Subjects
LUNG cancer; INTERLEUKIN-17; INFLAMMATION; CANCER invasiveness; CANCER cell proliferation; NEOVASCULARIZATION; CELLULAR signal transduction
- Publication
Mediators of Inflammation, 2016, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2016/8494079