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- Title
Single Nucleotide Polymorphisms of the Serotonin Transporter Gene in Migraine – An Association Study.
- Authors
Bayerer, Bettina; Engelbergs, Jörg; Savidou, Irini; Boes, Tanja; Küper, Michael; Schorn, Christoph F.; Wissmann, Andreas; Knop, Dietmar; Diener, Hans C.; Limmroth, Volker
- Abstract
We report a case–control study with 251 unrelated migraine patients and 192 unrelated healthy controls to evaluate an association between the polymorphisms of the 5-HT transporter (5-HTT) gene rs2066713 and rs1979572 and different migraine phenotypes. We found a genetic association for the A allele of rs1979572 for migraine with aura (MA) especially in women as well as a significant lower prevalence for MA for carrier of the A allele of rs2066713 in women. These findings support previous results suggesting that the 5-HTT gene is involved in the polygenic etiology of MA. These data further suggest that women are more likely to be clinically affected by mutations in the 5-HTT gene than men.
- Subjects
GENETIC polymorphisms; NUCLEOTIDES; SEROTONIN; MIGRAINE; PHENOTYPES
- Publication
Headache: The Journal of Head & Face Pain, 2010, Vol 50, Issue 2, p319
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2009.01553.x