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- Title
Antibody Response and Acquired Tolerance of A/J Mice: Age- and Immunogen-Related Isotype Differences.
- Authors
Ponnappan, U.; Cinader, B.; Gerber, V.; Blaser, K.
- Abstract
In earlier work we have observed strain- and age-related diversity of immunological ageing in inbred mice pretreated with tolerogen or left without pretreatment and then immunized. Different isotypes show different age-and strain-related changes. Here, we extend this isotype analysis from C57BL/6 and SJL to A/J. By comparison with the first two of these, animals of strain A/J show very little age-related change, as judged by indirect plaque-forming response. We have found that in A/J, as in SJL and C57BL/6 mice, age-related changes are isotype-dependent. The age-related changes in isotype predominance and magnitude differ for different determinants. They depend on the structural relation between the tolerance-inducing or -sensitizing macromolecule and the immunogen.
- Subjects
IMMUNE response; IMMUNE complexes; ANTIGEN-antibody reactions; IMMUNOLOGY; AGING; MACROMOLECULES
- Publication
Scandinavian Journal of Immunology, 1988, Vol 27, Issue 4, p419
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1988.tb02366.x