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- Title
Analysis of the Quantity of Antiviral Antibodies from Mink Infected with Different Aleutian Disease Virus Strains.
- Authors
Aasted, B.; Tierney, G. S.; Bloom, M. E.
- Abstract
Mink persistently infected with Aleutian disease virus (ADV) develop hypergammaglobulinaemia and immune complex disease. Radiolabelled antibodies from mink infected with ADV-G, DK, Pullman, and Utah I strains of ADV were reacted against all four ADV strains in radioimmunoassay (RIA). The amount anti-ADV antibody in two equally hypergammaglobulinaemic serum pools varied from 13% (anti-Pullman) to 57% (anti-Utah I). Serum pools from two other sources (anti-DK and anti-ADV-G), although less hypergammaglobulinaemic, had 5% and 13%, respectively, indicating that 43-95% of the Ig in the sera of mink with AD was not specific antibody to ADV structural antigens. The possibility of a general polyclonal activation of the humoral immune system is being discussed. Comparison of plateau RIA binding levels for the four serum pools against the four viral antigens suggested three patterns of reactivity: DK anti Utah I reacted similarly, but Pullman and ADV-G reacted serologically different.
- Subjects
MINK Aleutian disease; SLOW virus diseases in animals; VIRAL diseases in minks; IMMUNOLOGIC diseases; IMMUNE system; ANTIGENS; IMMUNOGLOBULINS
- Publication
Scandinavian Journal of Immunology, 1984, Vol 19, Issue 5, p395
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1984.tb00947.x