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- Title
Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats
- Authors
Ertuğrul, Eylem Ertug; Çekin, İ. Engin; Cincik, Hakan; Doğru, Salim; Güngör, Atila
- Abstract
Abstract: Objective: The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury. Materials and Methods: After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30 mg/dL halofuginone solution for 5 minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis. Results: The fibrosis indexes of the treated group were significantly less than those of the control group (P < 0.05). Conclusions: Topically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
- Subjects
ANTIPROTOZOAL agents; DRUG efficacy; STENOSIS; LABORATORY rats; DISEASE management; CONTROL groups
- Publication
Otolaryngology-Head & Neck Surgery, 2009, Vol 140, Issue 5, p720
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2008.12.050