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- Title
Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis.
- Authors
Fogarty, Matthew J.; Noakes, Peter G.; Bellingham, Mark C.
- Abstract
Motor cortex layerVpyramidal neurons (LVPNs) regulate voluntary control of motor output and selectively degenerate (along with lower motor neurons) in amyotrophic lateral sclerosis. Using dye-filling and whole-cell patch clamping in brain slices, together with highresolution spinning disk confocal z-stack mosaics, we characterized the earliest presymptomatic cortical LVPN morphologic and electrophysiological perturbations in hSOD1G93A (SOD1) mice to date. Apical dendritic regression occurred from postnatal day (P) 28, dendritic spine loss from P21, and increased EPSC frequency from P21 in SOD1 LVPNs. These findings demonstrate extensive early changes in motor cortex of the SOD1 mouse model, which thus recapitulates clinically relevant cortical pathophysiology more faithfully than previously thought.
- Subjects
NEURONS; PYRAMIDAL neurons; MOTOR cortex; MOTOR neuron diseases; DENDRITIC cells; DISEASES
- Publication
Journal of Neuroscience, 2015, Vol 35, Issue 2, p643
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3483-14.2015