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- Title
Clearance of maternal leukaemic cells in a neonate.
- Authors
van der Velden, V. H. J.; Willemse, M. J.; Mulder, M. F.; Szczepański, T.; Langerak, A. W.; Wijkhuijs, J. M.; van Dongen, J. J. M.
- Abstract
A 36-week pregnant woman was diagnosed with acute lymphoblastic leukaemia. Delivery was initiated prematurely, and a healthy child was born. Cord blood and peripheral blood samples from the neonate (obtained at 6 weeks, 3 months and 6 months) were analysed for the presence of minimal residual disease by polymerase chain reaction analysis of a leukaemia-specific IGH gene rearrangement and the E2A–PBX1 fusion gene transcript. In the cord blood sample, a tumour load of ≈ 4 × 10-4 was found, whereas all later blood samples were negative. Our data indicate that the maternal leukaemic cells did not engraft in the neonate.
- Subjects
LYMPHOBLASTIC leukemia in children; MATERNAL-fetal exchange; METASTASIS; NEONATAL diseases; PREGNANCY complications
- Publication
British Journal of Haematology, 2001, Vol 114, Issue 1, p104
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2001.02914.x