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- Title
Levels of Serum D-Dimer among Patients with Aortic Intramural Haematoma.
- Authors
Yang, S-N.; Zhou, Z-Q.; Xiang, C-L.; Zhang, Q.; Jin, L-J.; Mao, X-L.
- Abstract
Objective: The aim of this study was to evaluate whether there was a difference of serum D-dimer between patients with aortic intramural haematoma and patients with classic acute aortic dissection. Methods: According to results of computed tomographic angiography, all the patients, who had an established diagnosis of acute aortic syndrome in the past four years in an affiliated hospital, were retrospectively classified into two groups: classic acute aortic dissection (AAD) group and aortic intramural haematoma (AIH) group. The serum D-dimer concentrations at admission and other clinical baseline characteristics between the two groups were compared. Furthermore, the occurrence of the main clinical complications was compared between the two groups. Fifty-one subjects were included. Thirty-eight patients (74.5%) were in the AAD group and thirteen (25.5%) in the AIH group. Results: D-dimer levels were significantly higher in AAD group (3.50 ± 1.72 mg/mL) than in AIH group (1.54 ± 1.50 mg/mL, p < 0.05). All patients with AAD had D-dimer levels above the threshold of 0.50 ng/mL (sensitivity 100%). However, two patients in the AIH group presented with D-dimer levels below the threshold. The sensitivity of the D-dimer test in detecting AIH was 84.6% (11/13). But there was no significant difference in sensitivity between the two groups (p > 0.05). The main clinical complication rate was 39.5% (15/38) in the AAD group and 30.8% (4/13) in the AIH group (p > 0.05). Conclusion: D-dimer levels are lower in patients with AIH than those in patients with AAD. Although it shows no difference of sensitivity between AAD and AIH, D-dimer can be negative in AAD patients. Moreover, patients with AIH have a similar clinical evolution during hospitalization compared to patients with AAD.
- Subjects
HEMATOMA; AORTIC dissection; FIBRIN fragment D; ANGIOGRAPHY; BLOOD serum analysis; AORTIC diseases; PATIENTS
- Publication
West Indian Medical Journal, 2016, Vol 65, Issue 3, p500
- ISSN
0043-3144
- Publication type
Article
- DOI
10.7727/wimj.2014.368