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- Title
Transition‐Metal‐Free α‐C‐Alkylation of Oxindoles with Alcohols.
- Authors
Duan, Yu‐Tong; Wang, Zhong‐Xia
- Abstract
Transition‐metal‐free α‐C‐alkylation of oxindoles with alcohols was performed. The reaction requires the presence of LiOtBu and proceeds under thermal conditions. The method exhibits a wide scope of substrates. Both primary and secondary aliphatic and aromatic alcohols can be employed as the alkylating reagents. Oxindole and various 1‐alkyl‐ or 1‐aryl‐substituted oxindoles can be alkylated. The mechanistic studies show that the reaction may involve both free radical and aldol condensation/MPV processes.
- Subjects
OXINDOLES; ALDOL condensation; ALIPHATIC alcohols; ALKYLATION; ALCOHOL; FREE radicals
- Publication
Asian Journal of Organic Chemistry, 2023, Vol 12, Issue 5, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300015