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- Title
Pd‐Catalyzed Mizoroki‐Heck Annulation and Equivalent Aminocarbonylation Reactions Enabled by Mo(CO)<sub>6</sub>‐Mediated Direct Reduction of Nitro Derivatives.
- Authors
Xu, Shujuan; Liu, Huahua; Zhu, Jia; Wei, Li; Chen, Zhiyuan
- Abstract
A Pd‐catalyzed Mizoroki‐Heck annulation/equivalent aminocarbonylation reaction of alkene‐tethered aryl iodides with nitro compounds is accomplished, providing facile access to diverse carbamoyl‐substituted benzoheterocycles, such as indolin‐2‐ones and 2,3‐dihydrobenzofurans, in moderate to good yields. The cost‐effective Mo(CO)6 complex is discovered to be a solid carbonyl (CO) source and an ideal reducing agent, enabling the efficient production of the desired benzoheterocycles with broad substrate scope tolerance, including both nitroarenes and nitroalkanes under external reductant‐free conditions.
- Subjects
NITROAROMATIC compounds; ANNULATION; CARBONYLATION; ISOINDOLE; SONOGASHIRA reaction; REDUCING agents; NITROALKANES
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 12, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202200497