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- Title
Triple Therapy with Ranitidine or Lansoprazole in the Treatment of Helicobacter pylori-Associated Duodenal Ulcer.
- Authors
Lazzaroni, M.; Bargiggia, S.; Porro, G. Bianchi
- Abstract
Objective: The aim of this study was to verify the efficacy--in the cure of duodenal-ulcer associated H. pylori infection--of ranitidine 300 mg taken late in the evening or lansoprazole 30 mg taken before breakfast, coupled with clarithromycin and metronidazole. Methods: Eighty patients with endoscopically proven active duodenal ulcer were randomized to take ranitidine or lansoprazole for 4-8 wk, together with clarithromycin 250 mg b.i.d. and metronidazole 500 mg b.i.d, for the first 2 wk. Endoscopic controls, as well as histological and urease tests for H. pylori, were performed at entry and after 4 and 8 wk. Results: According to intent-to-treat analysis, ulcers were healed after 4 wk in 36/40 patients (90%) with ranitidine and in 38/40 (95%) with lansoprazole. After 8 wk, the healing percentage with ranitidine and lansoprazole was 97% (39/40) and 95% (38/40), respectively. H. pylori was eradicated in 85% of the patients taking ranitidine and in 90% of those taking lanzoprazole. Side effects were reported in 25 % of the patients in both groups. Conclusions: Our results confirm that the combination of ranitidine, clarithromycin, and metronidazole can be considered an alternative to proton pump inhibitors in terms of clinical efficacy and economy.
- Subjects
DUODENAL ulcers; HELICOBACTER pylori; HELICOBACTER pylori infections; METRONIDAZOLE; ANTIPARASITIC agents; PROTON pump inhibitors; ANTIHISTAMINES; STOMACH ulcers
- Publication
American Journal of Gastroenterology (Springer Nature), 1997, Vol 92, Issue 4, p649
- ISSN
0002-9270
- Publication type
Article