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- Title
CD4+CD161+ T Lymphocytes Infiltrate Crohn's Disease-Associated Perianal Fistulas and Are Reduced by Anti-TNF-α Local Therapy.
- Authors
Maggi, Laura; Capone, Manuela; Giudici, Francesco; Santarlasci, Veronica; Querci, Valentina; Liotta, Francesco; Ficari, Ferdinando; Maggi, Enrico; Tonelli, Francesco; annunziato, Francesco; Cosmi, Lorenzo
- Abstract
Background: Crohn's disease (CD) is an idiopathic inflammatory bowel disease (IBD) in the pathogenesis of which both Th1 and Th17 lymphocytes have been described as being involved. The NK-associated molecule CD161 has recently been described as a marker of IL-17-producing lymphocytes. In this work we assessed the presence and the functional features of CD161 T helper lymphocytes infiltrating CD-associated perianal fistulas, both before and after inoculation of anti-TNF-α mAbs along the fistula. Methods: In a group of 9 CD patients with fistulizing perianal disease, we evaluated phenotypic and functional features of T cells recovered from the fistula, comparing them with peripheral blood (PB) T lymphocytes. Moreover, the effects anti-TNF-α mAbs injections along the fistula in terms of ability to reduce the inflammatory infiltrate and to determine fistula disappearance were assessed. Results: In CD patients with fistulizing disease there is an accumulation of CD161+ T helper lymphocytes, with higher frequencies of Th1, Th17 and Th17/Th1 cells in the fistula than in PB. Local anti-TNF-α administration is associated with fistula resolution in the majority of patients with disappearance of infiltrating T lymphocytes, without any systemic effect in circulating effector T cells. Conclusions: These findings suggest that CD4+CD161+ T cells with Th17, Th17/Th1 and Th1 phenotype accumulate in CD perianal fistulas, and indicate local anti-TNF-α mAbs administration along the fistula as a promising tool for the treatment of these patients. Copyright © 2012 S. Karger AG, Basel
- Subjects
INFLAMMATORY bowel disease treatment; ANAL fistula; T cells; TUMOR necrosis factors; INFLAMMATORY bowel diseases; BIOMARKERS
- Publication
International Archives of Allergy & Immunology, 2013, Vol 161, Issue 1, p81
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000343467