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- Title
Versatile nanostructured processing strategy for bone grafting nanocomposites based on collagen fibrillogenesis.
- Authors
Wang, X. M.; Wang, X. L.; Ma, J. F.; Jiang, J. M.; Zheng, G. Q.; Chen, Z. H.; Li, X. D.
- Abstract
Strong bone-like nanocomposites of collagen type I and hydroxyapatite were prepared by coupling the in situ synthesis, hybrid gel formation and subsequent dehydration consolidation. The calcium phosphate synthesis was initiated at 4°C in the concentrated collagen monomeric solutions. Under this condition collagen molecules inhibited the calcium phosphate uncontrollably rapid growth and the predominant collagen fibril aggregation was retarded. Elevating temperature induced collagen fibrillogenesis leading to the formation of elastic hybrid gels. The dehydration consolidation of the elastic gels gave rise to strong nanocomposites. The mechanical properties and bone-like characteristics of the prepared nanocomposites were explicated. The in situ formation of a hybrid gel together with its facile processing capability suggests the versatility of this biomimetic strategy either in fabricating different structural forms (films, scaffolds and monoliths) of bone grafts or in further inclusion of other biosubstance into the nanocomposites.
- Subjects
COLLAGEN; HYDROXYAPATITE; CALCIUM phosphate; BIOSYNTHESIS; BONE grafting; BIOMIMETIC chemicals
- Publication
Advances in Applied Ceramics: Structural, Functional & Bioceramics, 2009, Vol 108, Issue 6, p384
- ISSN
1743-6753
- Publication type
Article
- DOI
10.1179/174367608X372907