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- Title
Antiadipogenic Effects of Aster glehni Extract: In Vivo and In Vitro Effects.
- Authors
Heon-Myung Lee; Gabsik Yang; Tae-Gue Ahn; Myung-Dong Kim; Agung Nugroho; Hee-Juhn Park; Kyung-Tae Lee; Wansu Park; Hyo-Jin An
- Abstract
Aster glehni (AG) is a Korean traditional herb that grows in Ulleungdo Island, Republic of Korea. None of the several reports on AG include a determination of the effect of AG on adipogenesis. The primary aim of this study was to determine whether AG attenuates adipogenesis in mouse 3T3-L1 cells and epididymal fat tissue. AG blocked the differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner and suppressed the expression of adipogenesis-related genes such as PPARγ, C/EBPα, and SREBP1c, the master regulators of adipogenesis. Male C57BL/6J mice were divided randomly and equally into 4 diet groups: control diet (CON), high-fat diet (HFD), HFD with 1% AG extract added (AG1), and HFD with 5% AG extract added (AG5). The experimental animals were fed HFD and the 2 combinations for 10 weeks. Mice fed HFD with AG gained less body weight and visceral fat-pad weight than did the mice fed HFD alone. Moreover, AG inhibited the expression of important adipogenic genes such as PPARγ, C/EBPα, SREBP1c, LXR, and leptin in the epididymal adipose tissue of the mice treated with AG1 and AG5. These findings indicate antiadipogenic and antiobesity effects of AG and suggest its therapeutic potential in obesity and obesity-related diseases.
- Subjects
SOUTH Korea; PREVENTION of obesity; ACADEMIC medical centers; ANALYSIS of variance; ANIMAL experimentation; BIOPHYSICS; FAT cells; HIGH performance liquid chromatography; RESEARCH methodology; BOTANIC medicine; MICE; POLYMERASE chain reaction; RESEARCH funding; WESTERN immunoblotting; GENOMICS; DATA analysis software; IN vitro studies
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2013, Vol 2013, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2013/859624