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- Title
Amino acids, L-Cysteine and L-Methionine, Attenuate Activation of Rat Stellate Cells in Primary Culture.
- Authors
Matsui, Hiroko; Takashima, Tokuko; Maeda, Naoto; Imanishi, Yukihiro; Uyama, Naoki; Okuyama, Hiroaki; Kawada, Norifumi
- Abstract
A conference paper on the effect of amino acids on rat hepatic stellate cells is presented. Results reveal that L-cysteine and L-methionine reduces the protein level of PDGFR beta and IGF-IR beta. This causes desensitization of stellate cells to PDGF-BB and IGF-I. Intracellular signal cascades are attenuated, resulting in the inhibition of DNA synthesis of stellate cells.
- Subjects
AMINO acids; KUPFFER cells; METHIONINE; PROTEINS; CELL culture; DNA synthesis
- Publication
Comparative Hepatology, 2004, Vol 3, p1
- ISSN
1476-5926
- Publication type
Conference Paper