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- Title
Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial.
- Authors
Park, Seonyoung; Kim, Ah-Young; Cho, Hyeonseok; Baik, Deborah; Lee, Hankil; Cho, Sunghwa; Kang, Hye-Young
- Abstract
<bold>Background: </bold>Patients with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL) treated with pralatrexate have previously shown superior overall survival (OS) compared to those who underwent conventional chemotherapy (CC, 15.4 vs. 4.07 months). We conducted an economic evaluation of pralatrexate from a societal perspective in Korea based on data from the PROPEL phase II study.<bold>Methods: </bold>Using a Markov model with a weekly cycle, we simulated the experience of patients with R/R PTCL receiving pralatrexate or CC for 15 years. The model consists of five health states; initial treatment, treatment pause, subsequent treatment, stem cell transplantation (SCT) success, and death. Comparative effectiveness was based on PROPEL phase II single-arm study and its matched historical control analysis. Costs included drug, drug administration, monitoring, adverse event management, and SCT costs.<bold>Results: </bold>The incremental cost-effectiveness ratio of the base case was $39,153 per quality-adjusted life-year (QALY) gained. The results of one-way sensitivity analysis ranged from $33,949 to $51,846 per QALY gained, which remained within an implicit willingness-to-pay (WTP) threshold of anticancer drugs in Korea.<bold>Conclusions: </bold>Pralatrexate is a cost-effective intervention with improved OS and incremental costs within the WTP limit. Pralatrexate could function as a new therapeutic option for patients suffering from life-threatening R/R PTCL.
- Subjects
SOUTH Korea; T-cell lymphoma; COST effectiveness; STEM cell transplantation; CLINICAL trials; MARKOV processes; FOLIC acid antagonists; CANCER relapse; CASE-control method; RESEARCH funding; PHARMACODYNAMICS
- Publication
BMC Cancer, 2020, Vol 20, Issue 1, pN.PAG
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-020-07629-z