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- Title
Direct causes of death in Japanese patients with hypopituitarism as analyzed from a nation-wide autopsy database.
- Authors
Hidesuke Kaji; Kazuo Chihara
- Abstract
OBJECTIVES: The direct causes of death in Japanese patients with hypopituitarism remain unclear. In this study, the direct causes of death were investigated and compared between Japanese patients with hypopituitarism from a nation-wide autopsy database and an age- and gender-matched control population from national reports. SUBJECTS: Three hundred and ninety-one subjects with hypopituitarism who had died were selected from a nation-wide autopsy database (19841993). The ratios of each cause of death among the age- and gender-matched control population were derived from national reports. RESULTS: In subjects with hypopituitarism, an increased relative frequency of death from cerebrovascular diseases (male; 2.02 (95% confidence interval (CI) 1.452.82), female; 1.73 (95% CI 1.182.52)) was found. In particular, the relative frequency of death from cerebral hemorrhage was 4.60 (95% CI 2.957.17) in male and 4.80 (95% CI 2.907.94) in female subjects with hypopituitarism. Unexpectedly, a decreased relative frequency of death from all heart diseases (male; 0.439 (95% CI 0.2770.696), female; 0.267 (95% CI 0.1490.478)) was found in subjects with hypopituitarism, although there was no difference between subjects with hypopituitarism and controls in the frequency of death from ischemic heart disease. CONCLUSIONS: These results provide useful information for the long-term care of Japanese patients with hypopituitarism.
- Subjects
PITUITARY necrosis; CORONARY disease; FORENSIC medicine; LONG-term care facilities
- Publication
European Journal of Endocrinology, 2004, Vol 150, Issue 2, p0149
- ISSN
0804-4643
- Publication type
Article