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- Title
Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients.
- Authors
De Lorenzo, Rebecca; Loré, Nicola I.; Finardi, Annamaria; Mandelli, Alessandra; Cirillo, Daniela M.; Tresoldi, Cristina; Benedetti, Francesco; Ciceri, Fabio; Rovere-Querini, Patrizia; Comi, Giancarlo; Filippi, Massimo; Manfredi, Angelo A.; Furlan, Roberto
- Abstract
Background and aims: Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU). Methods: We collected blood from 104 patients infected with SARS-CoV-2 the day of admission to the emergency room and measured blood neurofilament light chair (NfL), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and total tau protein levels. Results: We found that NfL, GFAP, and tau were significantly increased in patients with fatal outcome, while NfL and UCH-L1 in those needing ICU transfer. ROC and Kaplan–Meier curves indicated that total tau levels at admission accurately predict mortality. Conclusions: Blood neural markers may provide additional prognostic value to conventional biomarkers used to predict COVID-19 outcome.
- Subjects
TAU proteins; COVID-19; GLIAL fibrillary acidic protein; DEUBIQUITINATING enzymes; CYTOPLASMIC filaments
- Publication
Journal of Neurology, 2021, Vol 268, Issue 12, p4436
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-021-10595-6