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- Title
Antithrombotic therapy with Transcatheter aortic valve replacement.
- Authors
Dobesh, Paul P.; Goldsweig, Andrew M.
- Abstract
Aortic valve replacement is a necessary management strategy for patients with severe aortic stenosis. The use of transaortic valve replacement (TAVR) has increased significantly over the last decade and now exceeds traditional surgical aortic valve replacement. Since the valve systems used in TAVR consist of bioprosthetic valve tissue encased in a metal stent frame, antithrombotic therapy recommendations cannot be extrapolated from prior data with differently constructed surgical bioprosthetic or mechanical valves. Data on the use of antithrombotic therapy with TAVR are a rapidly developing area of medicine. Choice of agents depends on several patient factors. Patients undergoing TAVR also have a relatively high incidence of subclinical valve thrombosis. The clinical impact of this phenomenon and the implications for antithrombotic therapy continue to evolve. It is critical for clinicians who treat patients undergoing TAVR to have a firm understanding of practice guidelines, the evolving evidence, and its implications for the use of antithrombotic therapy in these patients.
- Subjects
AORTIC valve; HEART valve prosthesis implantation; FIBRINOLYTIC agents; AORTIC valve transplantation; BIOPROSTHETIC heart valves; AORTIC stenosis
- Publication
Pharmacotherapy, 2023, Vol 43, Issue 10, p1064
- ISSN
0277-0008
- Publication type
Article
- DOI
10.1002/phar.2847