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- Title
Novel thermosensitive hydrogel injection inhibits post-infarct ventricle remodelling.
- Authors
Tao Wang; De-Qun Wu; Xue-Jun Jiang; Xian-Zheng Zhang; Xiao-Yan Li; Jin-Feng Zhang; Zhao-Bin Zheng; Renxi Zhuo; Hong Jiang; Congxin Huang
- Abstract
Aims: Myocardial infarction (MI) remains the commonest cause of cardiac-related death throughout the world. Adverse cardiac remodelling and progressive heart failure after MI are associated with excessive and continuous damage of the extracellular matrix (ECM). In this study, we hypothesized that implantation of hydrogel into infarcted myocardium could replace the damaged ECM, thicken the infarcted wall, and inhibit cardiac remodelling.
- Subjects
MYOCARDIAL infarction; EXTRACELLULAR matrix; CARDIAC surgery; HYDROGELS; CORONARY disease
- Publication
European Journal of Heart Failure, 2009, Vol 11, Issue 1, p14
- ISSN
1388-9842
- Publication type
Article
- DOI
10.1093/eurjhf/hfn009