We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Crosslinking strategies for porous gelatin scaffolds.
- Authors
Van Vlierberghe, Sandra
- Abstract
The present work reports on the application and the evaluation of a multitude of crosslinking approaches including high-energy irradiation, redox-initiating systems and conventional carbodiimide-coupling chemistry for frozen and/or freeze-dried porous gelatin scaffolds. The latter is particularly relevant for a plethora of biomedical applications such as tissue engineering supports, wound dressings, adhesive and absorbent pads for surgery, etc. Moreover, the results obtained for gelatin can be considered a proof-of-concept to be extrapolated to other polymer systems containing double bonds and/or amines and carboxylic acids to also realize scaffold crosslinking in dry or frozen state. The results showed that high-energy irradiation at −5 °C enabled sufficient segmental mobility to induce chemical crosslinking after performing a cryogenic treatment of methacrylamide-modified gelatin scaffolds. Alternatively, although several redox-initiating systems were unable to chemically crosslink functionalized gelatin, the combination of ammonium persulphate and TEMED resulted in the formation of scaffolds with a reasonable gel fraction. Interestingly, carbodiimide-coupling was found suitable to crosslink freeze-dried gelatin matrices.
- Subjects
CROSSLINKING (Polymerization); GELATIN; OXIDATION-reduction reaction; POROUS materials; CARBODIIMIDES; TISSUE engineering
- Publication
Journal of Materials Science, 2016, Vol 51, Issue 9, p4349
- ISSN
0022-2461
- Publication type
Article
- DOI
10.1007/s10853-016-9747-4