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- Title
Burden of cardiovascular disease in Japanese cancer patients and survivors: a single cancer-center study in Niigata City.
- Authors
Okura, Yuji; Takayama, Tsugumi; Ozaki, Kazuyuki; Tanaka, Hiroshi; Seki, Hiroshi; Takenouchi, Tatsuya; Sato, Nobuaki; Minamino, Tohru
- Abstract
Background: Cardiovascular disease (CVD) and cancer are major causes of death in Japan. As most CVDs are chronic and often aggravate, long-term follow-up is necessary. Although some cancer patients and survivors have CVD, its prognostic significance and prevalence are unknown. Therefore, we conducted a retrospective study at our center to determine the prevalence of cancer patients with CVD.Methods: In 2015, our 10-year (2005-2014) cancer registry was summarized. Comorbidities including left ventricular dysfunction, atrial fibrillation (AF), ischemic heart disease, aortic stenosis, venous thromboembolism (VTE), and elevation of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were examined.Results: In total, 26,235 de novo cancer patients were registered and 16,130 survived until January 1, 2015. The 5-year survival rate was 64.0% for all cancer patients and 44.2% for cancer patients with CVD. Cox proportional hazards analysis adjusting for age, cancer stage, and body mass index revealed that AF [hazard ratio (HR) 1.219, male; P = 0.038], VTE (HR 1.517, male; P = 0.003 and HR 2.089, female; P < 0.001), and NT-proBNP elevation (HR 1.861, female; P = 0.002) were significantly associated with death. The CVD prevalence among cancer survivors in 2015 was 8.7% vs 3.5% for males vs females. AF was the most common CVD (prevalence: male, 4.0%; female, 1.0%). The prevalence of most CVD in adults increased progressively with age, with male predominance (12.1% for male and 7.5% for female patients in the 80 s age group).Conclusions: One in 10 elderly cancer survivors has serious CVD. AF, VTE, and heart failure were critical comorbidities. Cardiologists and cancer-care providers should recognize CVD presence and monitor patients closely, providing medications or interventions concurrently with cancer therapy.
- Subjects
JAPAN; HEART failure; CANCER patients; BRAIN natriuretic factor; CARDIOLOGISTS; CEREBRAL embolism &; thrombosis; CARDIOVASCULAR diseases; HEART diseases
- Publication
International Journal of Clinical Oncology, 2019, Vol 24, Issue 2, p196
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-018-1341-0