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- Title
Current views on chronic rejection after lung transplantation.
- Authors
Verleden, Geert M.; Vos, Robin; Vanaudenaerde, Bart; Dupont, Lieven; Yserbyt, Jonas; Van Raemdonck, Dirk; Verleden, Stijn
- Abstract
Chronic lung allograft dysfunction ( CLAD) was recently introduced as an overarching term mainly to classify patients with chronic rejection after lung transplantation, although other conditions may also qualify for CLAD. Initially, only the development of a persistent and obstructive pulmonary function defect, clinically identified as bronchiolitis obliterans syndrome ( BOS), was considered as chronic rejection, if no other cause could be identified. It became clear in recent years that some patients do not qualify for this definition, although they developed a chronic and persistent decrease in FEV1, without another identifiable cause. As the pulmonary function decline in these patients was rather restrictive, this was called restrictive allograft syndrome ( RAS). In the present review, we will further elaborate on these two CLAD phenotypes, with specific attention to the diagnostic criteria, the role of pathology and imaging, the risk factors, outcome, and the possible treatment options.
- Subjects
LUNG transplantation; HOMOGRAFTS; PATIENTS; BRONCHIOLITIS; BRONCHIOLE diseases
- Publication
Transplant International, 2015, Vol 28, Issue 10, p1131
- ISSN
0934-0874
- Publication type
Article
- DOI
10.1111/tri.12579