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- Title
Characterization of soluble PD-L1 in pleural effusions of mesothelioma patients: potential implications in the immune response and prognosis.
- Authors
Carosio, Roberta; Fontana, Vincenzo; Mastracci, Luca; Ferro, Paola; Grillo, Federica; Banelli, Barbara; Canessa, Pier Aldo; Dessanti, Paolo; Vigani, Antonella; Morabito, Anna; Pfeffer, Ulrich; Poggi, Alessandro; Roncella, Silvio; Pistillo, Maria Pia
- Abstract
Purpose: Programmed death-ligand 1 (PD-L1) protein plays a central role in the antitumor immune response, and appears to be a predictor of prognosis and efficacy for PD-L1 and programmed death 1 (PD-1) blockade therapy. The immunoregulatory role and prognostic impact of PD-L1 soluble form (sPD-L1) have been investigated in biological fluids of patients with different tumors. In malignant pleural mesothelioma (MPM), circulating sPD-L1 has been recently reported in patients' sera, but no data are available in pleural effusions (PE). In our study, we evaluated the baseline expression levels of sPD-L1 in PE from 84 MPM patients and correlated them with PD-L1-status in matched tumors and patients' overall survival (OS). Methods: sPD-L1 in PE was determined by ELISA and tumor PD-L1 by immunohistochemistry. Association of sPD-L1 with OS was estimated using the Cox regression model. Results: We observed that sPD-L1 was variably expressed in all the PE and tended to be higher (by 30%) in patients with PD-L1-positive tumors (cut-off ≥ 1% stained cells) as compared to patients with PD-L1-negative tumors (geometric mean ratio = 1.28, P value = 0.288). sPD-L1 levels were significantly higher than those of sPD-1 (P value = 0.001) regardless of the MPM histotypes and they were positively correlated (r = 0.50, P value < 0.001). Moreover, high PE sPD-L1 concentrations were associated with a trend towards increased OS (hazard ratio 0.79, 95% CL 0.62–1.01, P value = 0.062). Conclusions: Our study documents the presence of sPD-L1 in PE of MPM patients, and suggests its possible biological and prognostic role in MPM.
- Subjects
PLEURAL effusions; PROGRAMMED death-ligand 1; IMMUNE response; MESOTHELIOMA; PROGNOSIS
- Publication
Journal of Cancer Research & Clinical Oncology, 2021, Vol 147, Issue 2, p459
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-020-03457-7