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- Title
The course of non-infectious uveitis in pregnancy: a retrospective study of 79 pregnancies.
- Authors
Giorgiutti, S.; Jamilloux, Y.; Gerfaud-Valentin, M.; Bert, A.; Ballonzoli, L.; Kodjikian, L.; Korganow, AS.; Poindron, V.; Sève, P.
- Abstract
Purpose: The study aims to describe the course and management of non-infectious uveitis during pregnancy and postpartum period in European populations. Methods: A retrospective observational study in two tertiary centers in France was performed. Pregnant patients during the follow-up of a non-infectious uveitis as well as those with new-onset uveitis were included. The medical records were analyzed with a systematic collection of the characteristics of the uveitis, the treatment and evolution of the uveitis, and the course of the pregnancy including obstetric complications. Results: Seventy-nine pregnancies in 59 women were included: 48 patients (68 pregnancies) were followed for uveitis and 11 had a new-onset uveitis diagnosis. Most patients had idiopathic uveitis (32.2%) or sarcoid uveitis (27.1%). Among the patients followed for uveitis at the time of conception, there were 18 relapses (26.5%) requiring treatment escalation. Relapses occurred mainly in the two first trimester (n = 12) or during the postpartum period (n = 5) and were significantly associated with an active uveitis at the time of conception (OR = 9.2, 95% CI [1.57–48.4], p = 0.01). The characteristics of the new-onset uveitis were similar to those already existing before pregnancy. Obstetric complications occurred in 25 pregnancies (31.6%), mainly gestational hypertension and gestational diabetes. Conclusion: The frequency of non-infectious uveitis relapses decreases as pregnancy progresses, in agreement with data from other non-European studies. However, multidisciplinary monitoring should be advised, especially to uncontrolled patients at the time of conception.
- Subjects
FRANCE; UVEITIS; IRIDOCYCLITIS; PREGNANCY; GESTATIONAL diabetes; PUERPERIUM; RETROSPECTIVE studies
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2023, Vol 261, Issue 5, p1391
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-022-05949-3