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- Title
A meta-analysis of the use of a transanal drainage tube to prevent anastomotic leakage after anterior resection by double-stapling technique for rectal cancer.
- Authors
Shigeta, Kohei; Okabayashi, Koji; Baba, Hideo; Hasegawa, Hirotoshi; Tsuruta, Masashi; Yamafuji, Kazuo; Kubochi, Kiyoshi; Kitagawa, Yuko
- Abstract
<bold>Background: </bold>The safety and efficacy of transanal drainage tube (TDT) placement to decrease the risk of postoperative anastomotic leakage after rectal cancer surgery has not been validated. The objective of this meta-analysis was to evaluate the usefulness of a TDT for the prevention of anastomotic leakage after an anterior resection for rectal cancer.<bold>Methods: </bold>The PubMed and Cochrane Library databases were searched for studies comparing TDT and non-TDT. The endpoint utilized in this study was defined as the rates of anastomotic leakage and re-operation. The relative effects of these variables were synthesized using Review Manager 5.1 software.<bold>Results: </bold>Four trials including 909 participants (401 TDT cases and 508 non-TDT cases) met our inclusion criteria. The weighted mean anastomotic leakage rate was 4% [95% confidence interval (CI) 1-6%], and a significantly lower risk of anastomotic leakage was identified in the TDT group compared with the non-TDT group [odds ratio (OR) 0.30; 95% CI 0.16-0.55; p = 0.0001]. Furthermore, there were significant differences between the TDT and non-TDT groups in terms of the re-operation rate (OR 0.18; 95% CI 0.07-0.44; p = 0.0002). No significant covariates related to anastomotic leakage or re-operation were identified in meta-regression analysis. Both the anastomotic leakage and re-operation rates for all studies lay inside the 95% confidence interval boundaries. No visible publication bias was found by visual assessment of the funnel plot (Egger's test; anastomotic leakage: p = 0.056, re-operation: p = 0.681).<bold>Conclusions: </bold>Placement of a TDT is an effective and safe procedure that can decrease the rate of anastomotic leakage and re-operation after an anterior resection.
- Subjects
META-analysis; SURGICAL anastomosis; RECTAL cancer; COLON cancer; SURGERY; RECTAL surgery; PREVENTION of surgical complications; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RECTUM tumors; REOPERATION; RESEARCH; STAPLERS (Surgery); EVALUATION research; TREATMENT effectiveness; MEDICAL drainage; ODDS ratio; EQUIPMENT &; supplies
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2016, Vol 30, Issue 2, p543
- ISSN
1866-6817
- Publication type
journal article
- DOI
10.1007/s00464-015-4237-3