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- Title
Effects of carbon dioxide pneumoperitoneum on hemodynamics in cirrhotic rats.
- Authors
Tsuboi, S.; Kitano, S.; Yoshida, T.; Bandoh, T.; Ninomiya, K.; Baatar, D.
- Abstract
Background: The aim of our study was to investigate the effect of carbon dioxide pneumoperitoneum on systemic and splanchnic hemodynamics in cirrhotic rats. Methods: Sprague–Dawley rats (n = 80) were used in this study. Liver cirrhosis was induced by thioacetamide administration intraperitoneally (200 mg/kg body weight, twice a week for 16 weeks). The radioactive microsphere method was used to measure systemic and regional hemodynamic parameters before, 1 h after the start, and 1 h after the release of pneumoperitoneum. Results: Splanchnic blood flow and cardiac index were significantly depressed during pneumoperitoneum in liver cirrhosis and control groups, but no significant differences were seen between the two groups. In both groups, portal venous inflow decreased and hepatic arterial blood flow increased significantly during pneumoperitoneum. However, during pneumoperitoneum, total hepatic blood flow as a percentage of its value before pneumoperitoneum was lower in cirrhotic rats (71.0%) than in control rats (91.9%) (p <0.05, Mann–Whitney U-test). Conclusions: Carbon dioxide pneumoperitoneum markedly decreases total hepatic blood flow in cirrhotic rats due to the impaired hepatic arterial buffer response. Liver function should be carefully controlled in cirrhotic patients after laparoscopic surgery with pneumoperitoneum.
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2002, Vol 16, Issue 8, p1220
- ISSN
1866-6817
- Publication type
Article
- DOI
10.1007/s00464-001-9163-x