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- Title
Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2.
- Authors
Whiley, David M.; Goire, Namraj; Lambert, Stephen B.; Ray, Sanghamitra; Limnios, E. Athena; Nissen, Michael D.; Sloots, Theo P.; Tapsall, John W.
- Abstract
Objectives: Reduced susceptibility to extended-spectrum cephalosporins in Neisseria gonorrhoeae has, to date, been associated with three alterations: a mosaic penA allele encoding the penicillin-binding protein 2 (PBP2); A-del-mtrR, an adenine deletion in the mtrR promoter; and penB, comprising mutated alleles of PorBIb. In this study, we examined an association between reduced susceptibility to ceftriaxone and additional mutations in gonococcal PBP2.
- Subjects
NEISSERIA gonorrhoeae; CEPHALOSPORINS; PEPTIDES; CARRIER proteins; PENICILLIN; ADENINE
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 8, p1615
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkq187