We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sensors and regulators of intracellular pH.
- Authors
Casey, Joseph R.; Grinstein, Sergio; Orlowski, John
- Abstract
Protons dictate the charge and structure of macromolecules and are used as energy currency by eukaryotic cells. The unique function of individual organelles therefore depends on the establishment and stringent maintenance of a distinct pH. This, in turn, requires a means to sense the prevailing pH and to respond to deviations from the norm with effective mechanisms to transport, produce or consume proton equivalents. A dynamic, finely tuned balance between proton-extruding and proton-importing processes underlies pH homeostasis not only in the cytosol, but in other cellular compartments as well.
- Subjects
PROTONS; MACROMOLECULES; EUKARYOTIC cells; ORGANELLES; HYDROGEN-ion concentration; HOMEOSTASIS; CYTOSOL
- Publication
Nature Reviews Molecular Cell Biology, 2010, Vol 11, Issue 1, p50
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2820